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Keep track of Closely (1)phenobarbital will decrease the extent or result of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your reduce in fentanyl plasma concentrations, not enough efficacy or, maybe, growth of the